Nature Made TripleFlex contains glucosamine hydrochloride, chondroitin sulfate and MSM. Glucosamine may help maintain the structural integrity of joints by stimulating the production of glycosaminoglycans and proteoglycans, which are two essential building blocks of cartilage. Therefore, glucosamine is an essential component for maintaining healthy joints.* One study showed glucosamine improved knee function.* Chondroitin is a naturally occurring nutrient found in the connective tissues, which lubricate and cushion your joints. Chondroitin is thought to promote water retention in the spaces between the joints filled with synovial fluid. One meta-analysis showed a statistically significant improvement in joint function in those taking chondroitin sulfate.* MSM, or methylsulfonylmethane, is a source of inorganic sulfur for joint cartilage. Because sulfur is essential-for the formation of connective tissue, MSM has been studied for its use in promoting joint comfort.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.