Updated as of 10/10/2022: I have known that I have the MTHFR gene mutation for about 12 years now. Even after diagnosis, I was using a few other B-complexes which I though were o.k. for my condition, but I did not realize that the B6 was not methylated. Turns out B6 has to be in the form of Pyridoxal 5-Phosphate, NOT Pyroxidine, to be more bioavailable to those who have MTHFR and do not methylate properly. I never knew that until about 5 years ago; the doctor I tested with didn't explain that part. After this discovery, I researched various B-complex formulas, and picked this one. I also wanted a B-complex that had methylated folic acid and that did not have a super high dose of methylcobalamin (B12), since my blood was testing high for B12 already. This formula fit the bill very well. A few other tips: 1) The amount of methylated folic acid per capsule here is low (400mcg). If you only take one capsule per day, I would also recommend taking additional methyl-folate if you do not methylate. However, please first discuss with your chosen physician, if possible. 2) If you take B6 in its methylated form of Pyridoxal 5-Phosphate (a.k.a. P5P), you also need to take magnesium so that the P5P pathway will work properly. .Without at least some magnesium to work with, you may end up feeling tired and with lower energy, which is probably not what you want. 3) B6 - along with certain co-factors like magnesium, zinc, vitamin-C, and folate, is necessary for the production of certain neurotransmitters like GABA and norepinephrine, as well as for the conversion of tryptophan or 5-HTP into serotonin. So you may want to consider taking some of these additional co-factors to enhance your results with this product (only folate is included in this product, you would have to buy the rest separately). Also note: Tyrosine is also required for the synthesis of dopamine, but I have not tried taking that yet. I believe I have been low in neurotransmitter production, and my nervous system has been a mess, due to a 12-year highly stressful job and the resulting sky-high cortisol levels (Thankfully, I am no longer at that job!). It's been getting better slowly now.....it takes time and it's also very helpful to decrease your sugar and simple carb intake (e.g. white flour). 4) B6 and zinc are both needed for the production of pancreatic enzymes and hydrochloric acid, so if you have low stomach acid / poor digestion, this may help. (Zinc is not included in this formula but you may wish to add it if you are looking to help your production of digestive enzymes) In summary, this formula really helps with all the above, and it may help you too. Douglas Labs also makes a similar formula although it has some variation in it's mix. Best wishes to you. Addendum, additional updates since 2017: I had started taking this Thorne Basic B once a day plus an additional 50mg -100mg of P5P back in 2017-2018. Sometimes I would miss a day of both, I'm not perfect :). Eventually I got more disciplined and was taking the Basic B twice a day. I felt that was working better for me. Overall I can say for sure that the combo has helped to calm down my nervous system. I even went through some serious surgeries and medical procedures (extremely stressful) in 2017 and 2018, and in the past I would be a nervous wreck 24/7 and would not be able to calm down. However, I no longer get that uncontrollable anxiety anymore, although there can be some days where I can still fall into a depressive state. Magnesium powder or capsules have also helped keep me calmer (at bedtime), and I have taken some Skullcap, Ashwagandha, and/or Passionflower at times to further calm myself down as needed. Since 2018 I have also tried other methylated B-complex formulas like MethylPro, Douglas Labs, Pure Encapsulations, Nordic Naturals, and Metabolic Maintenance - just to experiment. However I keep returning to this one because it seems to work the best for my physiology. Together with the P5P, this has been like a lifeline for me. I hope it can work for you too if you decide to try it. Read more

I’ve been taking THORNE Vitamin B12 for 5 months now, and I can confidently say it’s one of the best B12 supplements I’ve tried! Here’s my honest breakdown: 🔹 What I Love: ✔️ Highly absorbable formula, THORNE uses methylcobalamin, the active form of B12, making it easier for the body to absorb. ✔️ Energy & mental clarity, Since taking this daily, I’ve noticed a huge improvement in my energy levels, and I no longer feel sluggish throughout the day. It has also helped with my mental focus and concentration. ✔️ Supports recovery & mood, This has been a game changer for me in recovering from sleep deprivation and anxiety. I feel more balanced and less fatigued. ✔️ Clean, high-quality ingredients, No unnecessary fillers, additives, or artificial ingredients. THORNE is a trusted brand that prioritizes purity. ✔️ No weird aftertaste, Some B12 supplements have a strong taste, but this one is neutral and easy to take. 🔹 What Could Be Better: ❌ Small bottle, I wish it came in a larger size, especially since I take 2 daily! ❌ Not the cheapest option, It’s a premium supplement, but given the quality, I think it’s worth it. 🔹 My Personal Experience: I originally started taking B12 to help with energy, nervous system support, and recovery from stress, and this supplement has exceeded my expectations. I feel more alert, less anxious, and overall healthier since incorporating it into my routine. It’s now a staple in my daily supplements! 🔹 Final Verdict: 10/10 ⭐️ Would I recommend it? Absolutely! If you need a high-quality, effective B12 supplement for energy, brain function, and nervous system support, this is one of the best options out there. Read more

Took a couple of extra weeks to arrive from the others ordered on the same day, however, the product itself is good Read more

جيد جدا Read more

Producto increible! Read more

Thorne is a good brand for supplement. This B Complex is very effective with the right formula not the cheaper one. The buyer is always fast on delivery and cooperative. Read more

if you are looking for a good B12 vitamin, then this is the one. Read more

Awesome product! Feeling better already Read more

Using it now for long time, i had no side effects. Read more

I used to take these back in the US, been looking for them for a while and pleased they are available now. They really help with my energy and focus levels. I take one a day and i can already notice a big difference vs the other brand I was using before Read more

Helped with dry skin as it contains vitamin b3 Read more

As described thanks vm Read more

Thorne B-Complex #12 has been a total game-changer for my energy levels. It’s like a secret weapon for those dragging afternoons—I feel more focused and less like I need a caffeine IV to get through the day. The active forms of B12 and folate make a big difference, especially if your body struggles to process the synthetic versions found in other supplements. I also love that it’s gentle on the stomach. I’ve taken it on an empty stomach without any issues, which is rare for a B-complex. The capsules are small and easy to swallow, and there’s no weird aftertaste or bright yellow “B-vitamin pee” (if you know, you know). The only downside is the price—it’s on the premium side, but with Thorne’s reputation for quality and clean ingredients, it’s worth it. Plus, with only one capsule a day, the bottle lasts longer than you’d think. If you’re looking for a high-quality B-complex that boosts energy, supports mood, and doesn’t mess with your stomach, this is it. 4.8/5 Read more