I am a 65 year old female who has had cancer twice, and have been in remission from stage 4 metastatic cancer for 11 years, due in part I believe to a regimen of supplements including resveratrol, quercetin, Vitamin C, Vitamin D3, and many others. I also walk 3 miles per day, and have tried to avoid sugar and refined carbs for much of that time. Throughout the years I have been following anti-aging and anti-cancer research, as a curious layperson. I have explored writings and videos by David Sinclair of Harvard, Leonard Guarente of MIT, and others, leading me to the recent reports on the postulated benefits to humans of NAD precursor, Nicotinimide Riboside. Leonard Guarente himself takes it, according to his Elyseum website. I started taking the recommended dose in early February, 2015, and can report some positive results, although I believe the dosage level is critical and probably varies widely, depending on one’s age and health status. My experience has been that the prescribed dose of 250 mg. is simply too much. It revved me up, but the rebound effect was very noticeable--exhaustion. A suitable analogy might be constantly gunning and red-lining one’s old, inefficient engine. So I cut back to a half dose every other day. Much better. I still feel energetic--and optimistic--but am not completely exhausted hours later after the initial burst of energy has waned. It would certainly seem logical that younger, healthy, and/or athletic folks already have sufficient amounts of NAD, so they probably wouldn't notice much if any improvement from supplementation with NR. However, old folks have NAD deficiency as a result of aging, and probably see a much greater benefit from supplementation with NR. which increases NAD. I am guessing that most of the folks reporting little or no benefit from NR are either younger & healthy and have plenty of NAD; or, perhaps are taking far more than they need, producing some sort of negative hormesis-like response; or are not taking complementary doses of resveratrol, or other pterostilbenes, which operate in tandem with NAD as a substrate to influence anti-aging sirtuins. An update: I am now 68 and still taking NR from various makers, who add various components along with NR (all Niagen based) and at various dosages.. The 250 mg. dose is now my standard, however, and I no longer have the exhaustion effect. I don't know why, but it is gone and I am feeling great. I always take resveratrol daily, and many other supplements as noted above. I am also considering the other NAD precursor which is starting to become available, nicotinamide mononucleotide, but the price has got to come down significantly and some major advantage over NR demonstrated. Another possible effect from taking the 250 mg. NR dose is noteworthy: my fasting blood sugar is now running in the 60's and 70's regularly, but I do not feel bad. I have been doing a form of intermittent fasting for some time, but even when I have a regular meal, a few hours later my fasting glucose is back in the 60's & 70's. I test it daily. This may in fact serve as a long-term indicator of the continued efficacy of NR. I have never had fasting glucose levels this low, before taking 250 mg. of NR daily. Read more

I feel like this had good effect on my energy level during the day. I know the effects are more cellular, but I think it makes a difference over time. Will continue to order. Read more

I had read articles about the human anti-aging trials starting this year so I took a chance on this. I'm 49 and I don't know about feeling 20 again, but I definitely feel like I'm 35 again. I started lifting weights again this past year (former college wrestler and coach) and had consigned myself to being to old to lift like I did even in my mid thirties. So I cut back on my workout routines, instead of doing 16 sets per muscle group, I had to cut back to 8 - 12 sets per muscle group. I figured at this age (going on 50) doing anything was good. Within 1 week of taking the Niagen I somehow had the energy to pump out 16 sets. I don't come home tired from work and only work out on weekends or have to slam caffeine pills and energy boosters to get a workout in. I feel good every day. I did my research and from what I gather this product works better for older people, the young body builders didn't report much of anything. But from my understanding this product helps protect the brain in contact sports, so I don't want to turn off everyone young. I have 3 sons that play football and if this product was cheaper I would put them on it. Read more

Great quality,good value. Read more

My experience after 2 months taking it, it’s very good. The lines around my eyes and mouth are literally fading and I am more energetic. Read more

Felt more tired useless Read more

Has a horrible scent to it like it’s something rotten Read more

Confusing advertising!!!!!! why the write NAD this have nothing to do with nAD + not even the ingredients 👎👎👎👎👎 Read more

Works well Read more