I wanted to report a severe case of edema - painful swelling of my lower legs after taking four 500 mg tablets over a 24 hour period. This may be a healing reaction but it hasn't subsided after seven days. It's also caused my skin to abrade, and even tear, when I use a wash cloth. I have psoriasis and have had chemo and immunotherapy for chronic lymphocytic leukemia, now under control. I've had edema before - after chemo, rituxan and even UVB light therapy. But this was the worst. Its swiftness and intensity surprised me. A reminder that curcumin augmented with piperine is an anti-TNF (tumor necrosis factor) agent, a poor man's Enbrel, no matter how well intended as an alternatives therapy. Enbrel reports that edema is a persistent reaction for 2.2% of users. I like that this stuff pulverizes (turn to powder) psoriasis scale. On the other hand, I feel ill-served not to have been forewarned of possible side effects. Bcz we're not talking about a spice. Check out Enbrel or PubMed for the full range of potential side effects. Takeaway: get started with some caution. 7/3/13: I waited a week for the edema to subside and tried curcumin again. This time only minor swelling and subsequently no averse reactions, even at 2500 mg a day. Appears to be helping; coupled with Dovonex I've seen 30-40% reduction in psoriasis intensity and scaling. In fact, no scaling to speak of and I've enter the phase of trying to reduce the skin discoloration that psoriasis leaves behind. 7/27/13: This is now the single most valuable component of my psoriasis regimen. I've had NO scaling, NO itching and NO need to pick my skin in the last three weeks. My psoriasis now is extensive skin discoloration but it's in a stable state that allows topical agents to be maximally effective. I've gained five pounds. 11/13/13: Stopped taking curcumin three months ago. Psoriasis is 75% cleared. Gained another FIFTEEN pounds!!! 1/15/14: Original psoriasis 95% cleared. Now have 150 new spots covering 4% of my body. Gained a total of 20 pounds. Starting to take a 2000 mgs of curcumin a day with minimal effect on the psoriasis directly. However I've been able to use UVB light therapy much more effectively than before using curcumin. I've used UVB without the wild itching that light exposure caused. Previously after using UVB I had to cover myself in vaseline; post curcumin I've had no discomfort with UVB therapy, and more effectiveness, though I've haven't yet built up to long exposure times. Read more

Started taking 6 months ago and no side effects. Happy with product. Read more

I read a study of curcumin being given to mice with cardiomegaly as part of congestive heart failure and the curcumin REVERSED the cardiomegaly. It will take the usual forever for them to finally get the human trials done and proper dosages established. In the meantime, my little miniature pinscher dog was given less than a month to live as his heart was so enlarged it had filled his upper chest. He also was drowning with fluid in his lungs. He had the terrible constant congestive heart failure cough as well. As there is really no treatment besides diuretics, I researched curcumin, found out that in most cases it relieves gastric problems (which he also had) as long as the dosage isn't more than it should be, and that Doctors Best Curcumin with BioPerine was the best product out there for a supplement. I had no idea of dosage, and started giving my 4 pound dog (miniature pinscher) 5 capsules a day mixed in with his wet dog food. I gradually raised it to 7 capsules with no ill effects. It has a mild peppery taste, but for the most part older dogs can't smell or taste food well anyway, so he liked me adding a little bit more spice to his food. It took a month, but his cough gradually subsided and then went away. A year went by. I ran out of money and stopped giving him the curcumin. There was a "grace period: of about 2 months and then the cough came back. I thought I'd just about killed him and there would be no more reversals. Wrong. Restarting the pills worked the same as the first time. Same thing happened the next year when I stopped the curcumin. The following 2 years as well. My dog will be 17 in one month. He has lived FOUR YEARS after being in the last stages of congestive heart failure. For those who need tangible proof, the best I can give you is that the dog's name is Bruno, a miniature pinscher, his vet is Dr. Wishnack in Poway Animal Emergency Hospital, and I have the four year old x-rays that show how bad he was. He was brought in to them on New Years Eve four years ago, totally limp in my arms. They brought him back that night, but the prognosis was he'd be gone sometime soon within the month. I have not gotten new x-rays to see what the internal physical changes are because I don't have the money. But I have everyone in my household as well as visiting family and friends who have seen the visible proof over four years that the congestive heart failure symptoms disappear when my dog is on a regular schedule of curcumin, and that they slowly come back when I stop giving it to him. I don't know what the dosage would be for other dogs or for humans for that matter. My trial and error method for dosing him was to see how much I could give him without gastric upset. He's 4 pounds and he takes seven capsules emptied into his food. I don't know if he could take less with the same effect, but I don't want to jinx it so I'll continue giving him the seven capsules. There doesn't seem to be any listed severe side effects from it, other than too much will give them a tummy ache, and there will be bright yellow poop.that can stain stuff. I've not seen any side effects from it with Bruno. In fact, the curcumin has another benefit. He always had gastric problems. In the x-rays he's had over the years, his stomach was always extended with a lot of gas, and when he ate the gas literally would be pushed out while food was coming in. With the curcumin, that doesn't happen. The only time the excess gas starts coming back is when the curcumin is stopped. His appetite was bad before, probably because of gas pain, and he was always trying to eat grass. Now he has a hearty appetite, and it seems like there are no gastric problems at all. Anyways. It works on mice. It works on a dog. Maybe it will also work on a human. That I can't tell you because I don't have any human "guinea pigs" to try it on. But I can tell you that if your dog has been diagnosed with congestive heart failure, put them on the Doctor's Best curcumin with BioPerine. Read more

Bought it for mother and she has been using it since 2 months and seems good. Certainly it's not bad or not useful Appreciable response Read more

Good quality. Read more

El producto es muy bueno pero en Amazon MX está muy caro. Sabiendo que el de 1000mg por cápsula lo encuentras a un buen precio que esté de 500mg en otro lugar. Read more

This curcumin supplement is easy on the stomach and appears to support inflammation management. It absorbs well and offers a natural option for joint and general wellness. A reliable choice for daily health. Read more

Very good Read more

Good Read more